Blanco C. Carrillo T. Castillo R. Quiralte J. Cuevas M., Latex allergy: clinical features and cross-reactivity with fruits. Ann Allergy 1994;73(4):277-81.
The authors determined the clinical features of latex-allergic patients, and latex-associated food hypersensitivities in a prospective study performed in their outpatient clinic that included a clinical questionnaire, skin prick tests with aeroallergens and foods, skin test with a latex extract, determination of total and specific IgE by CAP/RAST methods, and RAST inhibition. Latex and food allergies were diagnosed on the basis of a suggestive clinical history and a positive skin test with the corresponding allergen. A total of 25 patients were diagnosed as having latex allergy, with female predominance (23:2) and a mean age was 33 +/- 9.0 years,. There were nine greenhouse and six hospital workers. Latex-induced reactions included systemic anaphylaxis in nine patients (36%). Average total IgE was 161 IU/L, and it was within normal limits in 16 cases. Latex skin prick tests had excellent diagnostic precision with no adverse reactions, and CAP for latex diagnostic sensitivity was 80%. Forty-two food allergies were diagnosed in 13 of the patients (52%), and 23 of these consisted of systemic anaphylaxis. The most frequent food hypersensitivities were to avocado (9), chestnut (9), banana (7), kiwi (5) and papaya (3). Through RAST-inhibition, cross-reactivity among latex, avocado, chestnut, and banana was demonstrated. The authors conclude that latex allergy affects middle-aged women in certain professions at increased risk. Their data suggest the existence of a "latex-fruit syndrome," because 52% of our latex allergic patients had allergies to certain fruits.